Harman Patil (Editor)

Glycerophosphodiester phosphodiesterase

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EC number
  
3.1.4.46

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
86280-59-3

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, a glycerophosphodiester phosphodiesterase (EC 3.1.4.46) is an enzyme that catalyzes the chemical reaction

a glycerophosphodiester + H2O an alcohol + sn-glycerol 3-phosphate

Thus, the two substrates of this enzyme are glycerophosphodiester and H2O, whereas its two products are alcohol and sn-glycerol 3-phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is glycerophosphodiester glycerophosphohydrolase. Other names in common use include gene hpd protein, glycerophosphoryl diester phosphodiesterase, and IgD-binding protein D. This enzyme participates in glycerophospholipid metabolism.

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1O1Z, 1T8Q, 1V8E, 1VD6, 1YDY, 2DXL, 2DXN, 2OOG, and 2P76.

References

Glycerophosphodiester phosphodiesterase Wikipedia


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