In enzymology, a glucose-1-phosphatase (EC 220.127.116.11) is an enzyme that catalyzes the chemical reaction
alpha-D-glucose 1-phosphate + H2
D-glucose + phosphate
Thus, the two substrates of this enzyme are alpha-D-glucose 1-phosphate and H2O, whereas its two products are D-glucose and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is alpha-D-glucose-1-phosphate phosphohydrolase. This enzyme participates in glycolysis / gluconeogenesis.
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1NT4.