Gleeson is an Irish surname. It is an anglicisation of the Irish name Ó Glasáin or Ó Gliasáin. The name is most common in County Tipperary but originates in East County Cork, in the once powerful Uí Liatháin kingdom, where the Gleesons were great lords and sometimes kings. Notable people with the surname include:
Adrian Gleeson (born 1967), Australian rules football player
Brendan Gleeson (born 1955), Irish actor
Brian Gleeson (actor) (born 1987), son of Brendan
Brian Gleeson (Australian rules footballer) (born 1934)
Dan Gleeson (born 1985), English football player
Dave Gleeson (born 1968), Australian rock singer
Dermot Gleeson (born 1949), Irish barrister, government adviser, and businessman
Dermot Gleeson (born 1949), British governor of BBC
Domhnall Gleeson (born 1983), Irish actor, son of Brendan
Edward Burton Gleeson (1803–1870), South Australian pioneer, founder of the town of Clare
Hampton Gleeson (1834–1907), Australian miner, pastoralist, politician and brewer
Irene Gleeson (1944–2013), Australian humanitarian
Jack Gleeson (born 1992), Irish actor
James Gleeson (born 1915), Australian surrealist artist, poet, and writer
John Gleeson (disambiguation), multiple people
Johnny Tom Gleeson (1853-1924), Irish poet and songwriter
Keith Gleeson (born 1976), Irish Australian rugby union football player
Martin Gleeson (born 1980), English rugby league player
Martin Gleeson (born 1994), Australian rules football player
Murray Gleeson (born 1938), Australian jurist, Chief Justice of the High Court of Australia
Paul Gleeson (Labour Politician) (born 1955), Politician Boston, Lincolnshire
Robert Gleeson (1873–1919), South African cricketer
Sean Gleeson (born 1987), English rugby league player
Seán Gleeson (contemporary), British soap opera actor
Simon Gleeson (born 1977), Australian soap opera actor in the UK
Stephen Gleeson (born 1988), Irish professional football player
Trevor Gleeson (born 1966), Australian basketball coach
Father William Gleeson (1827-1903), Irish-American historian, linguist, and missionary priest.