Germanico is a serenata in one act, to a libretto of unknown authorship, which is ascribed to George Frideric Handel on the sole source, a copyist's manuscript in the library of the Conservatorio Luigi Cherubini in Florence. The ascription to Handel, "del sig. Hendl", is in the same hand that copied the music, suggesting it was contemporary with the writing of the score. It was discovered in 2007 by the conductor and scholar Ottaviano Tenerani and has been recorded by Deutsche Harmonia Mundi (EAN 886978604521). The work appears to be authentic and to date from the earliest phase of Handel's sojourn in Italy, probably around 1708, leading to claims that it was Handel's first Italian opera.
Despite the division into two acts, the work is described on the manuscript as a serenata, and it lacks the drama of conventional opera seria. Instead it is a work of rejoicing and prophecy, based around the historical figure of Germanicus Caesar and his victory over the German chieftain Arminius. Another character is Germanico's wife Agrippina the Elder – they were the parents of Agrippina the Younger, who is the central protagonist of Handel's later Italian opera Agrippina of 1710.