Entrez 9328 | Ensembl ENSG00000148308 | |
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Aliases GTF3C5, TFIIIC63, TFIIICepsilon, TFiiiC2-63, general transcription factor IIIC subunit 5 External IDs MGI: 1917489 HomoloGene: 40806 GeneCards: GTF3C5 | ||
General transcription factor 3C polypeptide 5 is a protein that in humans is encoded by the GTF3C5 gene.
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Model organisms
Model organisms have been used in the study of GTF3C5 function. A conditional knockout mouse line, called Gtf3c5tm2a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on mutant mice and two significant abnormalities were observed. No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; no additional significant abnormalities were observed in these animals.