Puneet Varma (Editor)

GSK1360707F

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PubChem CID
  
24802841

3D model (Jmol)
  
Interactive image

Formula
  
C14H17Cl2NO

Molar mass
  
286.196 g/mol

GSK1360707F httpsuploadwikimediaorgwikipediacommonsthu

GSK1360707F is a new and potent selective triple reuptake inhibitor. structurally related to amitifadine and NS-2359 (GSK-372,475).

Contents

Synthesis

  1. BOC Protecting group.
  2. Enolization and trapping with triflate group (cf Comins' reagent).
  3. Suzuki reaction
  4. Reduction (only 1 mol eq. LAH because N-BOC can be reduced to N-Me)
  5. Trifluoroacetic acid (TFA) removal of protecting group.
  6. Simmons–Smith reaction cyclopropanation.
  7. Williamson ether synthesis (c.f. NS patents & paxil).

PET

GSK1360707F has recently (2013) been tested on baboons (Papio anubis) & humans for transporter occupancy.

References

GSK1360707F Wikipedia
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