Neha Patil (Editor)

GRAP2

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Species
  
Entrez
  
9402

Human
  
Ensembl
  
ENSG00000100351

GRAP2

Aliases
  
GRAP2, GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, Mona, P38, GRB2-related adaptor protein 2

External IDs
  
MGI: 1333842 HomoloGene: 21007 GeneCards: GRAP2

GRB2-related adapter protein 2 also known as GRB2-related adaptor downstream of Shc (GADS) is a 37 kDa protein that in humans is encoded by the GRAP2 gene.

Contents

Function

This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.

Interactions

GRAP2 has been shown to interact with:

References

GRAP2 Wikipedia


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