Suvarna Garge (Editor)

GRAP

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Aliases
  
GRAP

Human
  
Ensembl
  
ENSG00000154016

Species
  
Entrez
  
10750

GRAP

External IDs
  
MGI: 1918770 HomoloGene: 4822 GeneCards: GRAP

GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene.

This gene encodes a member of the GRB2/Sem5 (C. elegans homolog)/Drk (Drosophila homolog) family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.

Interactions

GRAP has been shown to interact with Linker of activated T cells.

References

GRAP Wikipedia


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