Entrez 9052 | Ensembl ENSG00000013588 | |
Aliases GPRC5A, GPCR5A, RAI3, RAIG1, PEIG-1, TIG1, G protein-coupled receptor class C group 5 member A External IDs MGI: 1891250 HomoloGene: 2961 GeneCards: GPRC5A | ||
Retinoic acid-induced protein 3 is a protein that in humans is encoded by the GPRC5A gene.
Contents
Function
This gene encodes a member of the type 3 G protein-coupled receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoic acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation.
Post transcriptional regulation
GPRC5A is one of only a handful of genes known in the literature that are post-transcriptionally controlled by miRNAs through their 5'UTR.
Clinical Significance
GPRC5A is dysregulated in many human cancers and in other diseases.
References
GPRC5A Wikipedia(Text) CC BY-SA