Species Human Entrez 27202 | Human Mouse Ensembl ENSG00000134830 | |
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Aliases C5AR2, C5L2, GPF77, GPR77, complement component 5a receptor 2 External IDs MGI: 2442013 HomoloGene: 49549 GeneCards: C5AR2 | ||
C5a anaphylatoxin chemotactic receptor C5a2 also known as C5L2, G protein-coupled receptor 77, is a protein that in humans is encoded by the C5AR2 gene.
Function
The anaphylatoxins C3a, C4a, and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5a2 is coexpressed with the C5a receptor, (C5a1, C5aR, C5R1, CD88), on polymorphonuclear neutrophils and may modulate C5a1 activity.
References
GPR77 Wikipedia(Text) CC BY-SA