Aliases GPR35 Human Mouse Ensembl ENSG00000178623 | Species Human Entrez 2859 | |
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External IDs MGI: 1929509 HomoloGene: 3874 GeneCards: GPR35 | ||
G protein-coupled receptor 35 also known as GPR35 is a G protein-coupled receptor which in humans is encoded by the GPR35 gene. Heightened expression of GPR35 is found in immune and gastrointestinal tissues, including the crypts of Lieberkühn.
Contents
Agonists
Selective agonists of GPR35 include:
Antagonists
Antagonists of GPR35 include:
Clinical significance
Deletion of GPR35 gene may be responsible for brachydactyly mental retardation syndrome and is mutated in 2q37 monosomy and 2q37 deletion syndrome. In one study GPR35 has been recognised as a potential oncogene in stomach cancer.
References
GPR35 Wikipedia(Text) CC BY-SA