GPR158

Probable G-protein coupled receptor 158 is a protein that in humans is encoded by the GPR158 gene.

GPR158 is an orphan class C GPCR. It is highly expressed in the brain where it binds to RGS7, an inhibitor of G_i/o-coupled GPCR signaling, localizing it to the plasma membrane.

GPR158 is also expressed at lower levels in other organs. It shows an unusual subcellular localization pattern, being found at both the plasma membrane and in the nucleus.

GPR158 is an androgen-regulated gene that stimulates cell proliferation in prostate cancer cell lines. It is linked to neuroendocrine differentiation.