Species Human Entrez 139378 | Human Mouse Ensembl ENSG00000156920 | |
Aliases ADGRG4, PGR17, RP1-299I16, GPR112, adhesion G protein-coupled receptor G4 External IDs MGI: 2685213 HomoloGene: 72131 GeneCards: ADGRG4 | ||
G protein-coupled receptor 112 is a protein encoded by the ADGRG4 gene. GPR112 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
GPR112 is expressed in human enterochromaffin cells and in the mouse intestine. The N-terminal fragment (NTF) of GPR112 contains pentraxin (PTX)-like modules. GPR112 gene expression has been identified as a marker for neuroendocrine carcinoma cells.
References
GPR112 Wikipedia(Text) CC BY-SA