Entrez 23062 | Ensembl ENSG00000103365 | |
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External IDs MGI: 1921355 HomoloGene: 22860 GeneCards: GGA2 | ||
ADP-ribosylation factor-binding protein GGA2 is a protein that in humans is encoded by the GGA2 gene.
Contents
Function
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.
Interactions
GGA2 has been shown to interact with RABEP1, Sortilin 1, BACE2 and CLINT1.