Entrez 2563 | Ensembl ENSG00000187730 | |
Aliases GABRD, EIG10, EJM7, GEFSP5, gamma-aminobutyric acid type A receptor delta subunit External IDs MGI: 95622 HomoloGene: 55489 GeneCards: GABRD | ||
Gamma-aminobutyric acid receptor subunit delta is a protein that in humans is encoded by the GABRD gene.
Contents
Function
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABAA receptors, which are ligand-gated chloride channels. The GABAA receptor is generally pentameric. Its five subunits are alpha, beta, gamma, delta, and rho. The GABRD gene encodes the delta subunit.
Cell type-specific expression
In a technical comparison between quantitative reverse transcriptase PCR and digital PCR, the expression of the rat gabrd gene was examined across three cell types in the somatosensory cortex: neurogliaform cells, fast spiking basket cells and pyramidal cells. Gene expression was detected in all three cell types, but showed marked enrichment in neurogliaform cells versus the other cell types examined.