Aliases GABRB1 Human Mouse Ensembl ENSG00000163288 | Species Human Entrez 2560 | |
External IDs MGI: 95619 HomoloGene: 20221 GeneCards: GABRB1 | ||
Gamma-aminobutyric acid receptor subunit beta-1 is a protein that in humans is encoded by the GABRB1 gene.
Contents
Function
The gamma-aminobutyric acid A receptor (GABAA receptor) is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABAA receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia.
Clinical significance
Mice bearing mutant copies of this gene have been shown to be vulnerable to binge drinking of alcohol.
References
GABRB1 Wikipedia(Text) CC BY-SA