Aliases GAB1 Human Mouse Ensembl ENSG00000109458 | Species Human Entrez 2549 | |
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External IDs MGI: 108088 HomoloGene: 1542 GeneCards: GAB1 | ||
GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene.
Contents
Function
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. The encoded protein is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. The expression of GAB1 was also implicated in the biology of B cell malignancies, and is regulated by non-coding RNA (miRNA) termed miR-150.
Interactions
GAB1 has been shown to interact with:
References
GAB1 Wikipedia(Text) CC BY-SA