| G3BP1, G3BP, HDH-VIII, G3BP stress granule assembly factor 1|
MGI: 1351465 HomoloGene: 38096 GeneCards: G3BP1
Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene.
This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It was originally reported to bind specifically to the Ras-GTPase-activating protein by associating with its SH3 domain, but this interaction has recently been challenged. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
G3BP1 has been shown to interact with USP10. It also interacts with SND1.