Girish Mahajan (Editor)

G3BP1

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Covid-19
Species  Human
Entrez  10146
Human  Mouse
Ensembl  ENSG00000145907
G3BP1
Aliases  G3BP1, G3BP, HDH-VIII, G3BP stress granule assembly factor 1
External IDs  MGI: 1351465 HomoloGene: 38096 GeneCards: G3BP1

Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene.

This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It was originally reported to bind specifically to the Ras-GTPase-activating protein by associating with its SH3 domain, but this interaction has recently been challenged. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Interactions

G3BP1 has been shown to interact with USP10. It also interacts with SND1[5].

References

G3BP1 Wikipedia


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