Species Human Entrez 2867 | Human Mouse Ensembl ENSG00000126262 | |
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Aliases FFAR2, FFA2R, GPR43, free fatty acid receptor 2 External IDs MGI: 2441731 HomoloGene: 133911 GeneCards: FFAR2 | ||
Free fatty acid receptor 2 (FFA2) is a G-protein coupled receptor encoded by the FFAR2 gene.
Contents
Expression
FFAR2 mRNA is expressed in adipose tissue, pancreas, spleen, lymph nodes, bone marrow, and peripheral blood mononuclear cells. FFAR2 transcription is regulated by the XBP1 transcription factor which binds to the core promoter.
Function
Mouse studies utilizing Ffar2 gene deletions have implicated the receptor in the regulation of energy metabolism and immune responses. However, discrepancies between the pathways activated by FFAR2 agonists in human cells and the equivalent murine counterparts have been observed.
References
Free fatty acid receptor 2 Wikipedia(Text) CC BY-SA