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Francis Fane was born on 5 December 1752, the third son of Henry Fane of Wormsley and his third wife Charlotte, daughter of Richard Luther of Miles, near Ongar in Essex. He was educated at Corpus Christi, Cambridge, graduating in 1768.
He was Member of Parliament for the constituency of Lyme Regis from 11 June 1777 until 1780 and for Dorchester in the Parliaments of 1790, 1796, 1802, 1806.
Family
Fane married Anne Cooke, who succeeded to her father's estates in Somerset and Dorset in 1777. They had no children.