François-Xavier is a French masculine given name. Notable people with the name include:
François-Xavier Archambault (1841-1893), a lawyer and political figure in Quebec
François-Xavier Audouin (1765-1837), a French clergyman and politician during the French Revolution
François-Xavier Babineau (1825-1890), a Canadian Catholic priest
François-Xavier Bélanger (1833-1882), a French-Canadian naturalist and museum curator
François-Xavier Bellamy (born 1985), French philosopher and politician
François-Xavier Brunet (1868-1922), a Canadian Roman Catholic priest and bishop of Mont-Laurier, Québec
François-Xavier Cloutier (1848-1934), a Canadian Roman Catholic Bishop
François-Xavier de Donnea (born 1941), a Belgian politician
François-Xavier de Feller (1735-1802), a Belgian author
François-Xavier de Peretti, a French politician
François-Xavier Dulac (1841-1890), a farmer, merchant and political figure in Quebec
François-Xavier Dumortier (born 1948), a French Roman Catholic priest
François-Xavier Fabre (1766–1837), a French painter of historical subjects
François-Xavier Garneau (1809-1866), a French Canadian notary, poet, civil servant and liberal
François-Xavier Lalanne (1927-2008), a French sculptor and engraver
François-Xavier Larue (1763-1855), a farmer, notary and political figure in Lower Canada
François-Xavier Lemieux (1811-1864), a French Canadian lawyer and politician
François-Xavier Lemieux (Quebec MLA) (1851-1933), a Quebec lawyer, judge and political figure
François-Xavier Malhiot (1781-1854), a merchant, seigneur and political figure in Lower Canada
François-Xavier Méthot (1796-1853), a Quebec businessman and political figure
François-Xavier Nzuwonemeye, a former Rwandan soldier chiefly known for his alleged role in the Rwandan Genocide
François-Xavier Octavie Fontaine (1762-1812), a French military in the American War of Independence, the French Revolutionary Wars and the Napoleonic Wars
François-Xavier Ortoli (1925-2007), a French Gaullist politician and businessman
François-Xavier Paradis (1844-1910), a Canadian politician
François-Xavier Paré (1793-1836), a political figure in Lower Canada
François-Xavier Poizat (born 1989), a French pianist
François-Xavier Roth (born 1971), a French conductor
François-Xavier Tessier (1799-1835), a doctor, publisher and political figure in Lower Canada
François-Xavier Verschave (1945-2005), the founders of the French NGO Survie
François-Xavier Villain (born 1950), a member of the National Assembly of France
François-Xavier Wurth-Paquet (1801-1885), a Luxembourgian politician, jurist and archaeologist