Suvarna Garge (Editor)

Fosmidomycin

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Covid-19
ATC code  none
PubChem CID  572
ChemSpider  555
Molar mass  183.1 g/mol
CAS Number  66508-53-0
DrugBank  DB02948
UNII  5829E3D9I9
Fosmidomycin Wikipedia

Fosmidomycin meaning


Fosmidomycin is an antibiotic that was originally isolated from culture broths of bacteria of the genus Streptomyces. It specifically inhibits DXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. It is a structural analogue of 2-C-methyl-D-erythrose 4-phosphate. It inhibits the E. coli enzyme with a KI value of 38 nM (4), MTB at 80 nM, and the Francisella enzyme at 99 nM.

Contents

Fosmidomycin Fosmidomycin Wikipedia

How to pronounce fosmidomycin


Use in malaria

Fosmidomycin a Structure of fosmidomycin b Synthesis of fosmidomycin analogues

The discovery of the non-mevalonate pathway in malaria parasites has indicated the use of fosmidomycin and other such inhibitors as antimalarial drugs. Indeed, fosmidomycin has been tested in combination treatment with clindamycin for treatment of malaria with favorable results. It has been shown that an increase in copy number of the target enzyme (DXP reductoisomerase) correlates with in vitro fosmidomycin resistance in the lethal malaria parasite, Plasmodium falciparum.

Fosmidomycin Molecules Free FullText Synthetic Fosmidomycin Analogues with
Fosmidomycin FileFosmidomycin2svg Wikimedia Commons
Fosmidomycin Improved Efficacy of Fosmidomycin against Plasmodium and
Fosmidomycin craneinhibitorsjpg

References

Fosmidomycin Wikipedia


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