Species Human Entrez 668 | Human Mouse Ensembl ENSG00000183770 | |
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Aliases FOXL2, BPES, BPES1, PFRK, PINTO, POF3, forkhead box L2 External IDs MGI: 1349428 HomoloGene: 74992 GeneCards: FOXL2 | ||
Forkhead box protein L2 is a protein that in humans is encoded by the FOXL2 gene.
Contents
Function
FOXL2 is a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function.
Clinical significance
This protein is involved in sex determination. Female missing the FOXL2 gene appear male. FOXL2 knockout in mature mouse ovaries cause them to develop into testes, however oocytes are still formed.
Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3.
References
Forkhead box L2 Wikipedia(Text) CC BY-SA