Routes of
administration oral, topical Protein binding extensively | ATC code M01AG03 (WHO) Molar mass 281.2299 g/mol | |
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AHFS/Drugs.com International Drug Names Legal status AU: S4 (Prescription only) Metabolism | ||
Flufenamic acid is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs Like other members of the class, it is a COX inhibitor and prevents formation of prostaglandins. Flufenamic acid is known to bind to and reduce the activity of prostaglandin F synthase and activate TRPC6.
It is not widely used in humans as it has a high rate (30-60%) of gastrointestinal side effects. It is generally not available in the US. It is available in some Asian and European countries as a generic.
Scientists led by Claude Winder from Parke-Davis invented flufenamic acid in 1963, along with fellow members of the class, mefenamic acid in 1961 and meclofenamate sodium in 1964.
References
Flufenamic acid Wikipedia(Text) CC BY-SA