Routes of
administration Oral Legal status Investigational CAS Number 1050477-31-0 Molar mass 378.42 g/mol | ATC code none Synonyms BAY 94-8862 PubChem CID 60150535 | |
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Finerenone (INN, USAN) (developmental code name BAY-94-8862) is a non-steroidal antimineralocorticoid that is in phase III clinical trials for the treatment of chronic heart failure as of October 2015. It has less relative affinity to other steroid hormone receptors than currently available antimineralocorticoids such as eplerenone and spironolactone, which should result in fewer adverse effects like gynaecomastia, impotence, and low sex drive.
Contents
Pharmacology
Finerenone blocks mineralocorticoid receptors, which makes it a potassium-sparing diuretic.
This table compares inhibitory (blocking) concentrations (IC50, unit: nM) of three antimineralocorticoids. Mineralocorticoid receptor inhibition is responsible for the desired action of the drugs, whereas inhibition of the other receptors potentially leads to side effects. Lower values mean stronger inhibition.
The above-listed drugs have insignificant affinity for the estrogen receptor.
Chemistry
Unlike currently marketed antimineralocorticoids, finerenone is not a steroid but a dihydropyridine derivative.
Research
The drug is also being investigated in early trials for the treatment of diabetic nephropathy.