Kalpana Kalpana (Editor)

Fibronectin type II domain

Updated on
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Covid-19
Symbol  fn2
InterPro  IPR000562
PROSITE  PDOC00022
Pfam  PF00040
SMART  SM00059
SCOP  1pdc
Fibronectin type II domain

Fibronectin type II domain is a collagen-binding protein domain.

Fibronectin is a multi-domain glycoprotein, found in a soluble form in plasma, and in an insoluble form in loose connective tissue and basement membranes, that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in a number of important functions e.g., wound healing; cell adhesion; blood coagulation; cell differentiation and migration; maintenance of the cellular cytoskeleton; and tumour metastasis. The major part of the sequence of fibronectin consists of the repetition of three types of domains, which are called type I, II, and III.

Type II domain is approximately sixty amino acids long, contains four conserved cysteines involved in disulfide bonds and is part of the collagen-binding region of fibronectin. Type II domains occur two times in fibronectin. Type II domains have also been found in a range of proteins including blood coagulation factor XII; bovine seminal plasma proteins PDC-109 (BSP-A1/A2) and BSP-A3; cation-independent mannose-6-phosphate receptor; mannose receptor of macrophages; 180 Kd secretory phospholipase A2 receptor; DEC-205 receptor; 72 Kd and 92 Kd type IV collagenase (EC 3.4.24.24); and hepatocyte growth factor activator.

Human proteins containing this domain

BSPH1; ELSPBP1; F12; FN1; HGFAC; IGF2R; LY75; MMP2; MMP9; MRC1; MRC1L1; MRC2; PLA2R1; SEL1L;

  • Fibronectin type I domain: F12; FN1; HGFAC; PLAT;
  • References

    Fibronectin type II domain Wikipedia


    Similar Topics
    Executive Suite
    Mike Beard
    Jimmy Roye
    Topics
     
    B
    i
    Link
    H2
    L