Ferredoxin—NAD( ) reductase

Updated on Dec 12, 2024

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EC number 1.18.1.3 IntEnz IntEnz view ExPASy NiceZyme view		CAS number 39369-37-4 BRENDA BRENDA entry KEGG KEGG entry

In enzymology, a ferredoxin–NAD⁺ reductase (EC 1.18.1.3) is an enzyme that catalyzes the chemical reaction:

reduced ferredoxin + NAD⁺ ⇌ oxidized ferredoxin + NADH + H⁺

Thus, the two substrates of this enzyme are reduced ferredoxin and NAD⁺, whereas its 3 products are oxidized ferredoxin, NADH, and H⁺. This enzyme participates in fatty acid metabolism.

This enzyme belongs to the family of oxidoreductases, specifically those acting on iron-sulfur proteins as donor with NAD+ or NADP+ as acceptor.

The systematic name of this enzyme is ferredoxin:NAD⁺ oxidoreductase. There are a variety of names in common use:

ferredoxin–nicotinamide adenine dinucleotide reductase

ferredoxin reductase

NAD⁺-ferredoxin reductase

ferredoxin–NAD⁺ reductase

ferredoxin–linked NAD⁺ reductase

ferredoxin–NAD reductase

When NAD molecule is in its reduced form, the enzyme is referred to as:

NADH-ferredoxin oxidoreductase

reduced nicotinamide adenine dinucleotide-ferredoxin

NADH-ferredoxin reductase

NADH flavodoxin oxidoreductase

NADH₂-ferredoxin oxidoreductase

Other enzymes in the family include:

NADH-ferredoxin NAP reductase (component of naphthalene dioxygenase multicomponent enzyme system)

NADH-ferredoxin TOL reductase (component of toluene dioxygenase)

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1KRH.

References

Ferredoxin—NAD(+) reductase Wikipedia

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