Entrez 114793 | Ensembl ENSG00000157827 | |
External IDs MGI: 1918659 HomoloGene: 70871 GeneCards: FMNL2 | ||
Expression
Alternatively spliced transcript variants of the FMNL2 gene encoding different isoforms have been described. The full length FMNL2 (FRL3) protein (1092 amino acids-NCBI Reference Sequence: NP_443137.2) is regulated through autoinhibition, and may become activated through Rho proteins. The FMNL2 gene is expressed in multiple human tissues.
Function
Formin-like protein 2 is a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity.
Clinical significance
FMNL2 expression is considerably higher in colorectal cancer tumors compared to normal tissue.
References
FMNL2 Wikipedia(Text) CC BY-SA