Girish Mahajan (Editor)

FGF3

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Covid-19
Species  Human
Entrez  2248
Human  Mouse
Ensembl  ENSG00000186895
FGF3
Aliases  FGF3, HBGF-3, INT2, fibroblast growth factor 3
External IDs  MGI: 95517 HomoloGene: 3841 GeneCards: FGF3

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.

Contents

Function

FGF-3 is a member of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 (FGFR3) to serve as a negative regulator of bone growth during ossification. Effectively, FGF-3 inhibits proliferation of chondrocytes within growth plate.

FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.

Clinical significance

The FGF3 gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. Also, haploinsufficiency in the FGF3 gene is thought to cause otodental syndrome.

Interactions

FGF3 (gene) has been shown to interact with EBNA1BP2.

References

FGF3 Wikipedia


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