Species Human Entrez 26271 | Human Mouse Ensembl ENSG00000112029 | |
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Aliases FBXO5, EMI1, FBX5, Fbxo31, F-box protein 5 External IDs MGI: 1914391 HomoloGene: 8135 GeneCards: FBXO5 | ||
F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene.
Contents
Function
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.
Interactions
FBXO5 has been shown to interact with: