Species Human Entrez 9855 | Human Mouse Ensembl ENSG00000006607 | |
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Aliases FARP2, FIR, FRG, PLEKHC3, FERM, ARH/RhoGEF and pleckstrin domain protein 2 External IDs MGI: 2385126 HomoloGene: 8877 GeneCards: FARP2 | ||
FERM, RhoGEF and pleckstrin domain-containing protein 2 is a protein that in humans is encoded by the FARP2 gene.
Contents
Model organisms
Model organisms have been used in the study of FARP2 function. A conditional knockout mouse line, called Farp2tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on mutant mice and two significant abnormalities were observed. Homozygous mutant animals had a thickened cerebral cortex and displayed abnormal hair shedding.
Interactions
FARP2 has been shown to interact with PDZK1.