Species Human Entrez 157574 | Human Mouse Ensembl ENSG00000214050 | |
Aliases FBXO16, FBX16, F-box protein 16 External IDs MGI: 1354706 HomoloGene: 9273 GeneCards: FBXO16 | ||
F-box protein 16 is a protein that in humans is encoded by the FBXO16 gene.
Function
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene.