The film begins in Hudson, Ohio in 2004, where Scott "Scotty" Thomas (Scott Mechlowicz) is dumped by his girlfriend, Fiona (Kristin Kreuk), immediately after his high school graduation. With his best friend, Cooper Harris (Jacob Pitts), Scott attends a graduation party that evening where the band performs a song detailing the affair Fiona was having with the band's singer. Scott returns home drunk and angry and reads an e-mail from his German pen pal, Mieke (Jessica Boehrs), expressing sympathy for Scott and suggesting they meet in person. However, Scott has always misunderstood her name as "Mike", thinking that she is male. Cooper suggests that "Mike" may be a sexual predator, and Scott tells Mieke to stay away from him. Scott's younger brother informs him that "Mieke" is a common German girl's name. Realizing his mistake, and that he has feelings for Mieke, Scott tries to contact her again, but realises that Mieke has blocked his email address. Scott decides to travel to Europe, with Cooper, to find Mieke and apologize in person.
Scott and Cooper first travel to London, where they befriend a Manchester United football hooligan firm, led by Mad Maynard (Vinnie Jones). After a night of drinking, Scott and Cooper wake up on a bus on their way to Paris for a Manchester United match. In Paris, they meet up their classmates Jenny and Jamie (Michelle Trachtenberg and Travis Wester), fraternal twins who are touring Europe together. Jenny and Jamie decide to accompany Scott and Cooper to find Mieke in Berlin. The group travels to Amsterdam, where Jamie is robbed while receiving oral sex, losing everyone's money, passports, and train tickets. They attempt to hitchhike to Berlin, but due to a language misunderstanding end up in Bratislava. Finding a great exchange rate with the U.S. dollar, the group goes to a nightclub. Drunk on absinthe, Jenny and Jamie make out with each other, witnessed by Scotty and Cooper, and are horrified when they realize what they are doing. The next day, a Slovak man drives them to Berlin. Scott and Cooper soon establish that Mieke has left with a summer tour group, and will be reachable in Rome for only a short time. Jamie sells his camera to afford plane tickets to Rome.
In Rome, the friends head to the Vatican City, where Mieke is touring before her summer at sea. Inside the Vatican, Scott and Cooper search for Mieke, but accidentally ring the bell that signals pope has died. Scott appears on a balcony and spots Mieke in the crowd below. The Swiss Guards realize what is going on and detain Scott and Cooper, but they are rescued by the Manchester United hooligans. After some relationship advice from Mad Maynard, Scott is finally able to introduce himself to Mieke and confess his love. Mieke is happy to see him, and they have sex in a confessional booth. Mieke tells him to continue writing to her. On the flight back to Ohio, Jenny and Cooper have sex in one of the plane's lavatories while Jamie stays in Europe being hired by Arthur Frommer.
In the fall, Scott moves to Oberlin College. During a phone conversation with Cooper, now in a relationship with Jenny, Mieke knocks on his door, having been assigned to the same room due to another misunderstanding about her name. They embrace and get into bed together.
Writers Mandel, Berg, and Schaffer all directed while only Schaffer could achieve director credit, according to the DVD filmmaker commentary. Also according to the commentary track, all scenes were filmed in Prague, the Czech Republic, especially in the streets close to the Rudolfinum. The opening scene set in the United States was filmed at the International School of Prague. The scene where the main characters are boarding at the Paris railway station was filmed in Prague's main railway station (Hlavní nádraží). The scene inside Vatican City was actually filmed in Prague's National Museum. The scenes with a German lorry driver were taken at unfinished D5 motorway near Pilsen.
Review aggregation website Rotten Tomatoes gave the film a 46% rating based on 119 reviews. On Metacritic, the film scored 45 out of 100 based on 30 reviews.
In her review for Salon, Stephanie Zacharek wrote, "The giddy ridiculousness of Eurotrip is a pleasant surprise: The picture starts out slow and unsteady in its rhythms. But just when you begin to wonder if it’s ever going to get funny, or if it’s going to be merely desperate all the way through, it lifts off like a wobbly helicopter—and somehow it keeps flying." Ultra Culture blogger Charlie Lyne, who also introduced a screening of the film in 2011 at the Institute of Contemporary Arts, wrote that "EuroTrip is satire at its most brazenly self-loathing and audaciously entertaining."
In the New York Times, Elvis Mitchell wrote that "almost every girl in the movie with fewer than 10 lines to speak has to take her top off." In his review for Village Voice, Michael Miller critiqued the film for its "constant anxiety that women might turn out to be men and vice versa."
The film was released in the United States and Canada on February 20, 2004, in 2,512 theaters. Over its opening weekend, the film grossed $6.7 million. It went on to gross $17.8 million in the United States and Canada and $3 million in other territories, for a worldwide total of $20.8 million.
The film was released on DVD in the U.S. on June 1, 2004, in an R-rated theatrical version (90 minutes) and an "Unrated" extended version (92 minutes). The film was to premiere on HBO on April 2, 2005, but the studio scrapped the premiere due to the death of Pope John Paul II. In the film, there is an image of the Pontiff and a Vatican setting.
- "Scotty Doesn't Know" – Lustra
- "My Generation" – Chapeaumelon (The Who cover)
- "Wild One" – Wakefield
- "99 Red Balloons" – Goldfinger (Nena cover)
- "In the City" – The Jam
- "Shooting Stars" – Cauterize
- "Nonchalant" – Chapeaumelon
- "Scotty Doesn't Know" (Euro Version) – MC Jeffsky
- "Make My Dreams Come True" – Apollo 440
- "Du" – David Hasselhoff (Peter Maffay cover)
- "Les Promesses" – Autour De Lucie
- "Walking in the Clouds" – Basement Jaxx
- "I Love Marijuana" – Linval Thompson
- "Turn It Up" – Ugly Duckling
- "Get Loose" – The Salads
The film features additional tracks not included on the soundtrack album:"Morning Train (9 to 5)", a song by Sheena Easton plays after the football hooligans, having forced Scott and Cooper to "sing the Manchester United song", approve of Scott's altered ending to the song
"England 5 – Germany 1", a song by the seminal English Oi! band The Business, plays on the hooligan bus trip to Paris
"Prosper", a song by Maurice Chevalier is playing over the background in the scene at the Louvre when the panning camera stops and returns to ogle a beautiful brunette
"Two Tribes" by Frankie Goes To Hollywood plays during the robot fight scene outside the Louvre.
"Ça plane pour moi", a song by Belgian musician Plastic Bertrand, can be heard when the four friends first get on the train.
Donna Summer's 1979 hit "Hot Stuff" is featured in the scene where the four are on the train to Amsterdam.
"Let Forever Be", a song sung by Noel Gallagher of Oasis on lead vocals and performed by The Chemical Brothers. It can be heard in the unrated edition where the twins are seen drunkenly kissing each other
Bloodhound Gang's "The Bad Touch"; the song can be heard in the film when Cooper is walking in Amsterdam looking for Club Vandersexx.
"Keine Überdosis Deutschland", a song by Normahl, can be heard during the journey through Germany to Bratislava
"The Sacred War" during the visit in Slovakia
"Are You Gonna Be My Girl" by Jet is used during the flight from Berlin to Rome
"Horndog" by Overseer plays during the club scene in Eastern Europe