Born in Goondiwindi, Queensland, Lowe played his first junior rugby league for the Goondiwindi Boars. Upon entering high school, Lowe moved to Toowoomba where he attended Downlands College and later St. Mary's College. While living in Toowoomba he played rugby league for Valleys Toowoomba.
In 2008, Lowe was selected for the Australian Schoolboys side but was ruled out due to a wrist injury. That year he represented the Queensland Under 18 Maroons in a match against NSW Country.
After finishing high school, Lowe signed with the Sydney Roosters for the 2009 season. That year he played for the Newtown Jets SG Ball side and made his debut for the Roosters NYC team. Between 2009 and 2011, Lowe played 61 games and scored 19 tries for the Roosters under 20's team. In 2009, Lowe played for the Queensland Under 18's. In 2010, he was a member of the Junior Kangaroos squad, but did not play a game. In 2011, Lowe represented the Junior Kangaroos in a game against the Junior Kiwis.
In 2012, Lowe returned to Queensland to play with the Northern Pride RLFC. That season, Lowe was named the Intrust Super Cup Rookie of the Year.
In August 2012, Lowe signed a one year deal with the North Queensland Cowboys for the 2013 season.
In Round 12, Lowe made his NRL debut for the Cowboys against the Gold Coast Titans off the interchange bench, scoring a try in the Cowboys 31-12 loss at Cbus Super Stadium. On 5 August 2013, Lowe re-signed with the Cowboys for a further 2 years, keeping him at the club till the end of the 2015 season. Lowe played in 2 matches, scored 1 try and kicked 3 goals in his debut year in the NRL.
On 10 July, Lowe received a two match suspension from the NRL after being found to have placed a bet on an NRL matches. Lowe finished the season with him playing in 10 matches, scoring 3 tries and kicking 4 goals.
On 31 January and 1 February, Lowe played for the Cowboys in the 2015 NRL Auckland Nines. On 8 May, after establishing himself in the Cowboys' starting side, he re-signed with the club until the end of 2016. On 4 October, in the Cowboys' Queensland derby 2015 NRL Grand Final match against the Brisbane Broncos, he started at second row in the Cowboys' historic golden-point 17-16 win. He finished off his premiership winning 2015 season having played in all the Cowboys' 28 matches, scoring 4 tries and kicking 8 goals.
On 12 January, Lowe was selected in the QAS Emerging Origin squad. In February, he played for the Cowboys in the 2016 NRL Auckland Nines. On 21 February, he was a member of the Cowboys' 2016 World Club Challenge winning side, starting at second-row in the side's 38-4 victory over the Leeds Rhinos at Headingley Stadium.
On 1 July, Lowe re-signed with the Cowboys for a further 2 years, keeping him at the club until the end of the 2018 season.
On 14 September, Lowe was ruled out for the remainder of the 2016 season with a spinal cord injury.
In week two of the NRL Finals Series the North Queensland Cowboys defeated the Parramatta Eels 24-16 to proceed to the preliminary final. The victory was credit to Lowe, whom slotted important sideline conversions, and chasing down a runaway Will Smith allowing him to score in the corner in order for a difficult conversion. Lowe also made multiple try-saving tackles, and was a contender for man of the match.
North Queensland Cowboys Most Improved: 2016
2015 NRL Grand Final: North Queensland Cowboys – WinnersStatistics are correct to the end of the 2016 season
2016 World Club Challenge: North Queensland Cowboys – Winners