Rahul Sharma (Editor)

Estropipate

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AHFS/Drugs.com
  
Monograph

CAS Number
  
7280-37-7

DrugBank
  
DB04574

ATC code
  
none

PubChem CID
  
5284555

ChemSpider
  
4447610

Estropipate

Estropipate (INN, USAN, BAN) (brand names Harmogen, Improvera, Ogen, Ortho-Est, many others), also known as piperazine estrone sulfate, is a semi-synthetic, steroidal estrogen that is used mainly in hormone replacement therapy in the treatment of symptoms of menopause. It is a salt of estrone sulfate and piperazine, and is hydrolyzed into estrone in the body.

Contents

Uses

Estropipate is used to:

  • Alleviate symptoms of menopause as hormone replacement therapy
  • Treat some types of infertility
  • Treat some conditions leading to underdevelopment of female sexual characteristics
  • Treat vaginal atrophy
  • Treat some types of breast cancer (particularly in men and postmenopausal women)
  • Treat prostate cancer
  • Prevent osteoporosis

    • Pharmacology

    Estropipate is an agonist of the estrogen receptor (ER). In addition, estropipate has been found to act as an inhibitor of SLCO1B1 (OATP1B1) (IC50 = 70 nM).[1]

    References

    Estropipate Wikipedia
    (Text) CC BY-SA