Trade names Essentiale | ChemSpider none | |
Pregnancy
category US: N (Not classified yet) |
Essentiale (polyenylphosphatidylcholine or PPC, with or without synergistic vitamins) is a preparation of essential phospholipids. Essentiale normalizes the metabolism of lipids and proteins, improves the detoxification function of the liver, restores the cellular structure of the liver and retards the producing of conjunctive tissue. Essentiale medications are indicated for the treatment of fatty degeneration of the liver, hepatitis (including toxic hepatitis, liver damage caused by medicines or alcohol abuse), cirrhosis of the liver, disturbances in liver function associated with different illnesses.
Contents
Pharmaceutical action
Phospholipids are essential structural components of all cellular membranes. Essential phospholipids (substance EPL) - are the complex substances of natural origin (ethers of cholinephosphoric acid (phosphatidylcholine) and unsaturated fatty acids (linoleic, linolenic, olein). Essentiale medications possess the membranotropic properties, metabolic and hepatoprotective action; regulates lipid and carbohydrate metabolism. Essential phospholipids increase functional status of the liver.
While the disturbance of the liver metabolism essential phospholipids ensure the entering the high energy phospholipids, which are ideally combined with the endogenous phospholipids. Under the Essentialle phospholipids influence clinical and biochemical liver indexes are improved.
Combination of Essentiale with cordiamin (nikethamide) and vitamin E (50 mg/kg for 35 days) considerably activates the mono-oxygenase, glucoro- and glutathione transferase systems of the liver: and as a result the free-radical processes became less intense.
The spectrum of essential phospholipids' activity in chronic degenerative liver diseases can be described in the following properties:
Common use
Essentiale is used to treat the following diseases:
diabetes(the data suggests that Essentiale protects and improves liver function in diabetic subjects with non alcoholic fatty liver[3] ) and chronic infections);
Availability
Essentiale medications are manufactured under 4 trade names:
ESSENTIALE- solution for intravenous injections in vials 5 ml. Essentiale contains essential phospholipids(EPL substance) 250 mg, Pyridoxine chidrochloride 2,5 mg (Vitamin B6), Cyanocobolamine 0,1 mg (Vitamin B12), Sodium Pantothenate 1.5 mg, Nicotinamide 25 mg
ESSENTIALE FORTE N- Capsules N30 or N100. One capsule contains essential phospholipids (EPL substance) 300 mg.
ESSENTIALE N. -solution for intravenous injection in vials 5 ml. Essentiale N contains essential phospholipids(EPL substance) 250 mg.
ESSENTIALE FORTE – capsules N50. Essentiale forte contains essential phospholipids(EPL substance) 300 mg, Thiamine mono nitrate(Vitamin B1)6 mg, Riboflavine(Vitamiin B2) 6 mg, Pyridoxine chidrochloride 6 mg(Vitamin B6), Cyanocobolamine 0.06 mg (Vitamin B12), Nicotinamide 30 mg, Tocopherole acetate 6 mg(Vitamin E).
Contradiction and cautions
Do not use Essentiale in hypersensitivity or allergy to any ingredients of the preparation. The application of Essentiale in newborn children is not safe. During pregnancy women are recommended to consult their health care provider prior to taking Essentiale.
Side effects
In very rare cases it can cause :abdominal pain, nausea, diarrhea and allergic reaction(skin rash).
Recommendation for storage
Capsules should be stored at temperature not more than 20 °C. Vials should be stored at 2° - 8 °C
Independent researches
According to research conducted by Bronx Veterans Affairs Medical Center and the Mount Sinai School of Medicine in 2003, phospholipids treatment did not affect progression of liver diseases in those who continued to drink heavily.