Type Public Industry Pharmaceutical Founded 1998 | Traded as NASDAQ: ESPR Founder Dr. Roger Newton | |
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Key people Timothy M. Mayleben (president and CEO) Net income (US$26.1 million) (2013)
(US$11.7 million) (2012) Stock price ESPR (NASDAQ) US$ 31.33 +0.05 (+0.16%)7 Mar, 4:00 PM GMT-5 - Disclaimer Headquarters Ann Arbor, Michigan, United States | ||
Lipitor co discoverer roger newton on esperion therapeutics
Esperion Therapeutics, Inc. is a public, American pharmaceutical company focused on the development of a first-in-class, orally available, small molecule designed to significantly lower elevated levels of LDL-C - with the reduced potential for muscle-related side effects associated with statin use. The company is headquartered in Ann Arbor, Michigan.
Contents
History
Pfizer acquired the original Esperion in 2004 for US$1,300,000,000 as a defensive move to prevent ETC-216 from falling into competitors' hands. Two years later, in 2006, Pfizer decided to kill the Esperion organization and development of ETC-216. In May 2008, Dr. Roger Newton, Esperion's founder and chief scientific officer, who co-discovered the statin marketed as Lipitor® — the most commonly prescribed LDL-C lowering therapy in the world and best-selling drug in the pharmaceutical industry’s history, raised sufficient capital to acquire rights to ETC-1002 and Esperion from Pfizer, thereby leading to a second independent period for the company. In June 2013, Esperion became a public company again through an initial public offering. As of April 2014, Esperion was traded on NASDAQ under the symbol "ESPR".
ETC-1002
ETC-1002 is an innovative, first-in-class, orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies. ETC-1002 is absorbed rapidly in the small intestine and enters the liver through cell surface receptors different from those transporters that selectively take up statins.
Once in the liver, ETC-1002 inhibits ACL. Pre-clinical studies show that in the liver, ETC-1002 is converted to a derivative coenzyme, or ETC-1002-CoA, which directly inhibits ACL, a key enzyme that supplies substrate for cholesterol and fatty acid synthesis in the liver.
To date, Esperion has studied ETC-1002 in ten completed clinical trials and treated approximately 726 patients with ETC-1002 across completed Phase 1 and 2 studies.