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Erythravine is a tetrahydroisoquinoline alkaloid found in the plant Erythrina mulungu and other species of the genus Erythrina.
Contents
Nicotinic acetylcholine receptor
It has been shown in animal models to be a potent nicotinic receptor antagonist in animal models with an IC50 of 6µM at the α7 site and 13 nM for the α4β2 receptors.
Anxiolytic
It has anxiolytic effects in animal models of anxiety.
Anticonvulsant
Erythravine inhibited seizures evoked by bicuculline, pentylenetetrazole, and kainic acid as well as increasing the latency of seizures induced by NMDA. Treatment with Erythravine prevented death in all the animals tested with the four convulsants except a few of those treated with kainic acid.
References
Erythravine Wikipedia(Text) CC BY-SA