Born in Busto Arsizio, the Province of Varese, Pisano started his career at hometown club Varese,and won the Serie D Group A championship and was promoted. He also played for Varese in Eccellenza in 2004–05 season, played in the national promotion playoffs.
In 2006–07 season, he made his professional debut in Serie C2, completing the season in 11th place. In July 2007 he was sold to Serie B team Pisa in co-ownership deal. However, he only played 7 times in the second division, including once in the relegation playoffs.
In the next season he returned to Varese. (Varese gave up the remain 50% rights to Pisa in June 2008 and returned to Varese in co-ownership deal in August. In June 2009 Varese acquired the remaining 50% of Pisano's transfer rights from Pisa, and the player proved to be instrumental as his team became Lega Pro Seconda Divisione Group A champions in 2008–09 and then won the 2009–10 Lega Pro Prima Divisione playoffs, thus ensuring two consecutive promotions in a row. In the 2010–11 Serie B, Pisano appeared in 40 league games out of 42, and his team surprised once again as Varese ended the regular season in fourth place, then losing the promotion playoff semi-finals to Padova.
On 8 June 2011 Serie A team Palermo announced the signing of Pisano from Varese for €1.85 million. He made his debut in Serie A on 11 September 2011 in a 4–3 victory against Inter.
In January 2013 he was sold to Genoa in a co-ownership exchange deal for Brazilian defensive midfielder Anselmo. He returned to Palermo in June after the Sicilians, then relegated to Serie B, re-acquired full ownership of his transfer rights in a blind auction for €531,000, in a 3-year contract.
On 2 February 2015 he moved permanently to Verona, initially on a temporary deal. He was sold for free.
On 27 June 2017, Bristol City announced the signing of the free agent on a 2-year deal, effectively on 1 July.
He was capped once for Serie C under-20 representative team in 2006–07 Mirop Cup. He also capped for "U-20 Serie C" at Serie C Quadrangular Trophy, winning representative teams of Serie C2 Group B and C.
As of 15 July 2015.
1European competitions include the UEFA Champions League.Lega Pro Seconda Divisione: 2009
Serie D: 2006
2Other tournaments include the Supercoppa Italiana and Serie B relegation play–offs.