Rahul Sharma (Editor)


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Routes of administration  oral, inhalation
Metabolism  hepatic
CAS Number  84611-23-4
Protein binding  65%
ATC code  R05CB15 (WHO)
Biological half-life  1-3 hours
Molar mass  249.309 g/mol
AHFS/Drugs.com  International Drug Names

How to pronounce erdosteine

Erdosteine is a mucolytic. Specifically it is a thiol derivative developed for the treatment of chronic obstructive bronchitis, including acute infective exacerbation of chronic bronchitis. Erdosteine contains two blocked sulfhydryl groups which are released following first-pass metabolism. The three active metabolites exhibit mucolytic and free radical scavenging activity. Erdosteine modulates mucus production and viscosity and increases mucociliary transport, thereby improving expectoration. It also exhibits inhibitory activity against the effects of free radicals produced by cigarette smoke.


Clinical studies in patients with chronic obstructive lung disease have demonstrated the efficacy and tolerability of erdosteine. Erdosteine 300 mg twice daily reduced cough (both frequency and severity) and sputum viscosity more quickly and more effectively than placebo and reduced the adhesivity of sputum more effectively than bromhexine 30 mg twice daily.

Co-administration of erdosteine and amoxicillin in patients with acute infective exacerbation of chronic bronchitis resulted in higher concentrations of the antibiotic in the sputum, leading to earlier and more pronounced amelioration of clinical symptoms compared with placebo.

Erdosteine is associated with a low incidence of adverse events, most of which are gastrointestinal and generally mild. The LD50 is very high, 3,500-5,000 mg/kg.

Brand names


  • Erdomed
  • Erdopect
  • Erdostin
  • Erdotin
  • Evosten
  • Mucodox
  • Mucofor
  • Theovix
  • Tusselin
  • Vectrine
  • Other regions:

  • Asdigan
  • Biopulmin
  • Dostein
  • Dostin
  • Dostol
  • Ectrin
  • Edotin
  • Erdos
  • Esteclin
  • Fluidasa
  • Mucoflux
  • Mucotec
  • Mukial
  • Zertin
  • Vestein (Indonesia)
  • References

    Erdosteine Wikipedia