Supriya Ghosh

Eplivanserin

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Routes of administration  Oral
CAS Number  130579-75-8
ChemSpider  13267837
Molar mass  328.381 g/mol
ATC code  none
PubChem CID  5493160
UNII  3CO94WO6DJ
Eplivanserin httpsuploadwikimediaorgwikipediacommonsthu

What does eplivanserin mean


Eplivanserin (SR-46,349; planned trade name Ciltyri) was an experimental drug for the treatment of insomnia which was being developed by Sanofi Aventis.

Contents

Sanofi Aventis announced in December 2009 that it was withdrawing its application for approval of eplivanserin from both the U.S. Food and Drug Administration and the European Medicines Agency.

How to pronounce eplivanserin


Mechanism of action

Eplivanserin is an inverse agonist on the serotonin receptor subtype 5-HT2A. In contrast to older sedating drugs acting on 5-HT2A receptors (e.g., mirtazapine, clozapine, risperidone), eplivanserin has practically no affinity to dopamine, histamine and adrenergic receptors.

Study results

In a placebo controlled Phase II clinical trial with 351 subjects, eplivanserin reduced the sleep latency by 39 minutes (versus 26 minutes under placebo).

References

Eplivanserin Wikipedia


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