Species Human Entrez 1948 | Human Mouse Ensembl ENSG00000125266 | |
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Aliases EFNB2, EPLG5, HTKL, Htk-L, LERK5, ephrin B2 External IDs MGI: 105097 HomoloGene: 3019 GeneCards: EFNB2 | ||
Ephrin-B2 is a protein that in humans is encoded by the EFNB2 gene.
Contents
Function
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.
Interactions
EFNB2 has been shown to interact with EPHA3.
References
Ephrin B2 Wikipedia(Text) CC BY-SA