Endopolyphosphatase

In enzymology, an endopolyphosphatase (EC 3.6.1.10) is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are polyphosphate and H₂O, whereas its product is oligophosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is polyphosphate polyphosphohydrolase. Other names in common use include polyphosphate depolymerase, metaphosphatase, polyphosphatase, and polymetaphosphatase.