ATC code none PubChem CID 60768 ChemSpider 54765 Molar mass 396.52 g/mol | CAS Number 124378-77-4 IUPHAR/BPS 1646 UNII KJL283326C | |
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How to pronounce enadoline
Enadoline is a drug which acts as a highly selective κ-opioid agonist.
Contents
In human studies, it produced visual distortions and feelings of dissociation, reminiscent of the effects of salvinorin A.
It was studied as a potential analgesic, but abandoned because of the dose-limiting effects of dysphoria, which could be expected from a κ-opioid agonist. There was mention of its potential in treating comatose head injury or stroke victims, where that type of side effect would be immaterial.
Potency
When enadoline was first reported in 1990, it was "the most potent κ-selective analgesic ever reported ... 25 times more potent than morphine and 17 times more potent than U-62066".
References
Enadoline Wikipedia(Text) CC BY-SA