He began his career at Lodigiani and was signed by Fiorentina in 1998. In March 2001 he made his debut in Serie A under Roberto Mancini, before spending periods at Juventus, Modena, Parma and Bologna. In 2004, he was signed by Spaniards Valencia, where he won the Copa del Rey in 2007–08. In 2009, he returned to Italy where he spent four seasons with Genoa. In August 2013, he was signed by Torino.
Internationally, Moretti represented Italy at under-16 and under-20 youth levels. He was also part of the under-21 team that won the UEFA European Under-21 Championship and a bronze medal at the 2004 Summer Olympics. On 18 November 2014, he became the oldest player to debut for the Italy national football team, playing as a starter in a friendly against Albania.
Moretti started his career with local club Lodigiani, and in 2000 transferred to AC Fiorentina. He made his Serie A debut in March 2001, and was a member of the team that won the 2001 Coppa Italia. In the 2001–02 season, he played in 27 matches. Right before the Fiorentina bankruptcy, Moretti moved to Juventus in June 2002, and was loaned to Modena F.C. to help them avoid relegation. In 2003, Parma signed Moretti for €1.8M (part of Stephen Appiah's €2M loan), loaning him to Serie A team Bologna. In 2004, with Parma facing financial problems and Claudio Ranieri becoming head coach of Valencia CF, the left defender was traded to Valencia CF.
In the summer of 2004 he was transferred outright to Spanish club Valencia, who had already purchased fellow Italians Bernardo Corradi, Marco Di Vaio and Stefano Fiore. On 27 August, while remaining on the bench, he was part of the team that won the UEFA Super Cup, beating Porto 2–1. Claudio Ranieri would use Moretti predominantly at left-back, and, despite a difficult start due to competition with Fábio Aurélio and compatriot Amedeo Carboni, would soon earn the starting spot. He scored his first goal for Valencia on 28 November 2004 in the Primera División in a 2–0 home win against Mallorca. In the Champions League he played 4 games against Inter Milan, Werder Bremen and Anderlecht, with 29 appearances during the season.
The following season, he was a starter, making 33 appearances and a decisive contribution to the achievement of a third-place finish. At the beginning of the following season, on 6 November 2006, in the match against Espanyol, Moretti was seriously injured, damaging his lateral ligament of the knee, forcing him to the sidelines for more than three months. Despite the injury, the season remained one of the most important on a personal level and as a team, which reached the quarter-finals of the Champions League, defeated only by Chelsea. Moretti ended the year with 34 total appearances.
The 2007–08 season was not as positive, which concluded with Valencia tenth. Moretti remained a protagonist of the side, leading to Valencia's victory on 16 April 2008 in the 2008 Copa del Rey Final, playing all the matches from the initial stage to the final.
The following season, he was still a starter in the Spanish side, which reached the first knockout round of the UEFA Cup, which concludes the year sixth place in the Primera División. Moretti disputed 32 games.
After 172 appearances and 4 goals with the Spanish club, he returned to Italy to play for Genoa, engaged in the Europa League. The transfer fee was €3.5 million.
He made his debut for Genoa on 23 August 2009, a 3–2 victory at home against Roma. A week later he scored his first goal in red and blue colours against Atalanta. His first season with the Grifoni finished with 37 appearances and 1 goal in total. The following year, he only made 18 appearances under Gian Piero Gasperini, while the team finished the season in tenth place. The 2011–12 season is even more difficult for the team, and despite 27 appearances and a goal (against Inter Milan), Genoa finished in fourth last position. He was confirmed part of the Genoa defence for the 2012-2013 season, contributing 33 total appearances.
On 5 May 2013, he celebrated his hundredth appearances in Serie A with the shirt of Genoa, on the occasion of a match ending 4–1 against Pescara.
After being close to a renewal with Genoa, on 11 July 2013 he was signed by Torino for €700,000, on a two-year contract. He made his competitive debut for the Granata on 17 August, in Coppa Italia against Pescara. He scored his first official goal for Torino on 24 December in a 4–1 win against Catania. At the end of the season he extended his contract until 2016.
On 25 January 2015, he scored a goal in the 94th minute in which Torino defeated Inter Milan at San Siro after 27 years. It was his second goal for Torino.
On 30 August, he scored his first goal of the 2015–16 season, the equaliser in a 3–1 home win against Fiorentina. On 25 November, his contract was renewed until 2017. On 2 April 2017, he scored his first goal of the 2016–17 season in a 2–2 home draw against Udinese. On 5 April, his contract was renewed until 2018.
Moretti was in Italy's squad in the 1998 UEFA European Under-16 Championship, which the Azzurrini lost to Republic of Ireland in the final. With the under-21, he won the UEFA European Under-21 Football Championship and a bronze medal at the 2004 Summer Olympics football tournament.
On 9 November 2014, he was called up to the senior national team by Antonio Conte ahead of a UEFA Euro 2016 qualifying match against Croatia and a friendly against Albania. On 18 November, he was deployed as a starter in Genoa during a 1–0 win against Albania, becoming, at 33 years, 5 months and 7 days, the oldest player to debut for Italy.
A naturally left-footed defender, Moretti was originally an attacking left-back, but throughout his career he has often been used as a central defender. He is noted for his physicality, good positional sense, excellent technique, and ability in the air.
Updated 23 April 2017.Fiorentina
Coppa Italia (1): 2000–01
Supercoppa Italiana (1): 2002
Serie A (1): 2002–03
UEFA Super Cup (1): 2004
Copa del Rey (1): 2007–08
UEFA European Under-21 Championship (1): Germany 2004
Olympic bronze (1): Athens 2004
4th Class / Officer: Ufficiale Ordine al Merito della Repubblica Italiana: 2004