Adarna made her debut appearance in the film industry when she became part of the cast of the gag-comedy sketch TV series Bubble Gang in 2010. She was a series regular on the series until 2013. The series was well received from the public and garnered several awards, including Best Gag Television series. Meanwhile, in the film industry, she made her first appearance by starring in Si Agimat at si Eteng Kabisote (2010), playing only a minor role. Her career then went into expansion after she became part of the cast of Captain Barbell (2011) opposite Richard Gutierrez and Jillian Ward. Shortly after Captain Barbell, Adarna became part of Survivor Philippines: Celebrity Doubles Showdown (2011). She starred as herself and one of the Castaways of the series. She also made a cameo in the teen-oriented comedy drama film, Tween Academy: Class of 2012 (2011). The film was produced by GMA Films, and Adarna starred alongside Barbie Forteza, Elmo Magalona, Bea Binene, Jake Vargas, Joshua Dionisio, Kristofer Martin, Joyce Ching, Louise delos Reyes, Alden Richards, Derrick Monasterio, Lexi Fernandez, and Yassi Pressman.
She soon became part of the fantasy television series Alice Bungisngis and her Wonder Walis (2012), reuniting with her Tween Academy: Class of 2012 co-stars Derrick Monasterio and Lexi Fernandez. Adarna once again played a minor role in the film Boy Pick-Up: The Movie (2012), as one of the Bombshells. After Alice Bungisngis and her Wonder Walis, she then became a part of the prime time epic drama television series Indio (2013), playing a supporting character named Dalikmata, a woman who can tell the past, present or future. After portraying several supporting and minor roles in movies, Adarna then played the title role of a film entitled Ang Tag-araw ni Twinkle, and played the role of Twinkle. She then played a supporting role in the horror-themed movie Basement (2014), a film starring Betong Sumaya.
After being a GMA contract artist for 3 years, Adarna officially became a Kapamilya star after signing a contract with Star Magic in 2013. For her first ABS-CBN appearance, she became a contestant of the singing competition game show The Singing Bee (2014), and started appearing of ASAP (2014–present). Being a new transferee, Adarna guested on several interview series including The Buzz (2014). She later on guested on Vice Ganda's talk show Gandang Gabi, Vice! (2014).
Adarna got her first Kapamilya teleserye while starring in the science fiction romance television series Moon of Desire (2014). Adarna played the role of Tamara Herrera, the main antagonist. The series premiered on ABS-CBN's Kapamilya Gold afternoon block on March 31, 2014, and concluded on August 15, 2014, with a total of 97 episodes. In the series, Adarna starred alongside Meg Imperial, JC de Vera, and Dominic Roque. After Moon of Desire, Adarna made her leading role in the comedy romantic movie My Illegal Wife. The film was produced by Star Cinema. Adarna then starred in Beauty in a Bottle (2014) with Angelica Panganiban and Angeline Quinto.
In June 2015, she became part of the critically acclaimed prime time drama Pasión de Amor, a Philippine remake and adaptation of the 2003 drama Pasión de Gavilanes, a series also produced by Telemundo. She starred off with leading men, Jake Cuenca, Ejay Falcon, and Joseph Marco. Adarna was paired up with Ejay Falcon and the two made headlines as Sari (Adarna) and Oscar (Falcon). The series ended in February 2016. While doing Pasión de Amor, Adarna was part of You're Still the One, playing the role of Racquel, the woman who Jojo (Dennis Trillo) is engaged to.
She then reunited with Ejay Falcon for a second series together, while starring in The Greatest Love (2016). She played the role of young Gloria who appears in flashbacks when adult Gloria (Sylvia Sanchez) remembers her past with Peter (Ejay Falcon), because of the effects of her Alzheimer's disease. Adarna then became part of Langit Lupa, playing the role of Isa Sobrevista, the main antagonist.