Species Human Entrez 5266 | Human Mouse Ensembl ENSG00000124102 | |
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Aliases PI3, ESI, SKALP, WAP3, WFDC14, cementoin, peptidase inhibitor 3 External IDs HomoloGene: 122140 GeneCards: PI3 | ||
Elafin, also known as peptidase inhibitor 3 or skin-derived antileukoprotease (SKALP), is a protein that in humans is encoded by the PI3 gene.
Contents
Function
This gene encodes an elastase-specific protease inhibitor, which contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.
Clinical significance
Elafin has been found to have utility in serving as a biomarker for graft versus host disease of the skin.
Elafin plays some role in gut inflammation.
References
Elafin Wikipedia(Text) CC BY-SA