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EPB41

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Species  Human
Entrez  2035
Human  Mouse
Ensembl  ENSG00000159023
EPB41
Aliases  EPB41, erythrocyte membrane protein band 4.1, 4.1R, EL1, HE
External IDs  OMIM: 130500 MGI: 95401 HomoloGene: 44324 GeneCards: EPB41

Protein 4.1, also known as Beatty's Protein, is a protein associated with the cytoskeleton that in humans is encoded by the EPB41 gene. Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Protein 4.1 (80 kD) interacts with spectrin and short actin filaments to form the erythrocyte membrane skeleton. Mutations of spectrin and protein 4.1 are associated with elliptocytosis or spherocytosis and anemia of varying severity.

Contents

Clinical significance

Elliptocytosis is a hematologic disorder characterized by elliptically shaped erythrocytes and a variable degree of hemolytic anemia. Inherited as an autosomal dominant, elliptocytosis results from mutation in any one of several genes encoding proteins of the red cell membrane skeleton. The form discussed here is the one found in the 1950s to be linked to Rh blood group and more recently shown to be caused by a defect in protein 4.1. 'Rh-unlinked' forms of elliptocytosis are caused by mutation in the alpha-spectrin gene (MIM 182860), the beta-spectrin gene (MIM 182870), or the band 3 gene (MIM 109270) [supplied by OMIM].

Interactions

Band 4.1 has been shown to interact with:

  • CENPJ,
  • EIF3G
  • NUMA1, and
  • TJP2.
  • References

    EPB41 Wikipedia


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