Entrez 955 | Ensembl ENSG00000197586 | |
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Aliases ENTPD6, CD39L2, IL-6SAG, IL6ST2, NTPDase-6, dJ738P15.3, ectonucleoside triphosphate diphosphohydrolase 6 (putative) External IDs MGI: 1202295 HomoloGene: 68170 GeneCards: ENTPD6 | ||
Ectonucleoside triphosphate diphosphohydrolase 6 is an enzyme that in humans is encoded by the ENTPD6 gene.
Contents
Function
ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which is characteristic of NTPases.
Model organisms
Model organisms have been used in the study of ENTPD6 function. A conditional knockout mouse line called Entpd6tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping
References
ENTPD6 Wikipedia(Text) CC BY-SA