Entrez 1978 | Ensembl ENSG00000187840 | |
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Aliases EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I, eukaryotic translation initiation factor 4E binding protein 1 External IDs MGI: 103267 HomoloGene: 3021 GeneCards: EIF4EBP1 | ||
Eukaryotic translation initiation factor 4E-binding protein 1 is a protein that in humans is encoded by the EIF4EBP1 gene.
Contents
Function
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of cap-dependent mRNA translation.
Interactions
EIF4EBP1 has been shown to interact with:
References
EIF4EBP1 Wikipedia(Text) CC BY-SA